- Ray Culp, April 6, 1971 — One of the more underrated pitchers in club history, Culp shut down the Yankees with a complete game five-hitter, allowing one unearned run and striking out five in a 3-1 win.
- Ferguson Jenkins, April 9, 1976 — The future Hall of Famer pitched a complete game in taking the hard-luck 1-0 loss to Baltimore, the lone run scoring on a pair of fourth-inning errors. Jenkins walked none and struck out eight.
- Dennis Eckersley, April 10, 1982 — For 18 years the best recorded Opening Day start, Eckersley threw a complete-game shutout, scattering six hits while walking none and striking out six.
- Pedro Martinez, April 1, 1998; April 4, 2000 — Pedro's very first start with the Red Sox was amazing, as he poured in 11 strikeouts in seven shutout innings, walking two and allowing just three hits. He returned in 2000 with the Sox' best-ever opener, again walking two and striking out 11 in seven innings, but this time allowing just two hits.
For the record, the worst ever Opening Day start for the Red Sox was also Pedro Martinez, thanks to his inexplicable 2002 bomb — 3 IP, 9 H, 8 R, 7 ER, 2 BB, 4 K. He finished the season with 20 wins, leading the league in ERA and strikeouts while losing the Cy Young unjustly to Barry Zito. So don't fret, Yankee fans. There's hope for C.C. yet!